Routine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus. Issue 12 (29th October 2017)

• Record Type: Journal Article
• Authors: Dettmann, Inga M.; Krüger, Stine; Fuhrmann, Tarek; Rentzsch, Kristin; Karl, Ingolf; Probst, Christian; Komorowski, Lars; Fechner, Kai; van Beek, Nina; Lemcke, Susanne; Sárdy, Miklós; Bangert, Christine; Benoit, Sandrine; Hashimoto, Takashi; Zillikens, Detlef; Pas, Hendri H.; Jonkman, Marcel F.; Stöcker, Winfried; Schmidt, Enno
• Other Names: Antonicelli Frank guestEditor.; Ludwig Ralf J. guestEditor.
• Is Part Of: Experimental dermatology. Volume 26:Issue 12(2017)
• Page Start: 1267
• Page End: 1270
• Publication Date: 2017-10-29
• Subjects: atypical -- autoantibody -- diagnosis -- foliaceus -- vulgaris vegetans; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.13409
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: Autoantibodies against the 3 desmocollin (Dsc; Dsc1‐Dsc3) isoforms have been described in different pemphigus variants. Here, we developed state‐of‐the‐art detection systems for serum anti‐Dsc1, Dsc2 and Dsc1 IgG and IgA. These assays were applied in 5 different cohorts including pemphigus vulgaris (PV) patients with compatible direct immunofluorescence (IF) microscopy but no reactivity against desmogleins 1 and 3 (n = 24) and sera from patients with autoimmune blistering diseases with positive direct IF microscopy taken at the time of diagnosis (n = 749). We found that detection of anti‐Dsc serum reactivity is not helpful in the routine diagnosis of PV, pemphigus foliaceus and paraneoplastic pemphigus but may be valuable in pemphigus vegetans.