Successful treatment of bilateral endogenous Fusarium solani endophthalmitis in a patient with acute lymphocytic leukaemia. Issue 1 (22nd September 2017)

• Record Type: Journal Article
• Authors: Rizzello, Ilaria; Castagnetti, Fausto; Toschi, Pier Giorgio; Bertaccini, Patrizia; Primavera, Laura; Paolucci, Michela; Faccioli, Luca; Spinardi, Luca; Lewis, Russell E.; Cavo, Michele; Stanzani, Marta
• Is Part Of: Mycoses. Volume 61:Issue 1(2018)
• Page Start: 53
• Page End: 60
• Publication Date: 2017-09-22
• Subjects: antifungal therapy -- endophthalmitis -- fungal infection -- haematology -- vitrectomy -- voriconazole; Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/myc.12697
• Languages: English
• ISSNs: 0933-7407

Abstract

Summary: Fusarium spp. are an uncommon cause of fungaemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we describe a patient with acute lymphoblastic leukaemia and a prior history of extensive corticosteroid exposure who developed disseminated Fusarium solani infection following chemotherapy despite posaconazole prophylaxis. She was successfully treated with combination liposomal amphotericin B and voriconazole, intraocular injections of voriconazole, topical amphotericin B and bilateral vitrectomy. We also review published literature describing the management of endogenous Fusarium endophthalmitis in immunocompromised hosts.