Structures and bioactivities of seven flavonoids from Osmanthus fragrans 'Jinqiu' essential oil extraction residues. Issue 5 (4th March 2018)

• Record Type: Journal Article
• Authors: Zhou, Jiang-Lian; Fang, Xian-Ying; Wang, Jing-Qiu; Zhao, Lin-Guo; Li, Yi; Tang, Feng; Yue, Yong-De
• Is Part Of: Natural product research. Volume 32:Issue 5(2018)
• Page Start: 588
• Page End: 591
• Publication Date: 2018-03-04
• Subjects: O. fragrans flower residues -- flavonoid monomers -- antioxidant -- antitumour -- anti-inflammatory; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1318387
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Osmanthus fragrans are well-known for their fragrance, but it is wasteful if to discard O. fragrans flower after extracting their essential oils. In this paper, we found that O. fragrans flower residues were rich in flavonoids. Six flavonoids and one phenylethanoid glycoside were isolated from the ethanol extract of O. fragrans flower residues, identified as quercetin (1 ), rutin (2 ), verbascoside (3 ), genistin (4 ), kaempferol (5 ), isorhamnetin (6 ) and naringin (7 ). In bioactivity study, kaempferol (IC50 = 1.43 μg/mL) showed the best anti-inflammatory activity. Isorhamnetin, quercetin, kaempferol, verbascoside and rutin (the values of IC50 were 18.30, 11.05, 16.88, 20.21 and 22.76 μg/mL, respectively) showed excellent DPPH free radical scavenging activity. Verbascoside performed relatively well at inhibiting the growth of both CT26 colonic carcinoma cells (IC50 = 46.87 μg/mL) and HepG2 hepatocarcinoma cells (IC50 = 30.58 μg/mL). In addition, quercetin and kaempferol showed strong anti-proliferation activity against HepG2 cells. Abstract :