Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients with Breast Cancer from Two Medical Centers. (26th November 2017)

• Record Type: Journal Article
• Authors: Xiao, Guodong; Meng, Jinying; Zhang, Jing; Li, Gang; Du, Ning; Qin, Sida; Wang, Jichang; Xu, Chongwen; Ren, Hong; Tang, Shou-Ching; Sun, Xin
• Is Part Of: Cancer investigation. Volume 35:Number 10(2017)
• Page Start: 639
• Page End: 646
• Publication Date: 2017-11-26
• Subjects: Breast cancer -- 21-Gene recurrence score -- Cancer stem cells -- Recurrence risk; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2017.1405015
• Languages: English
• ISSNs: 0735-7907

Abstract

ABSTRACT: To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.