Identification of cell cycle-targeting microRNAs through genome-wide screens. Issue 23 (2nd December 2017)

• Record Type: Journal Article
• Authors: Hydbring, Per; Wang, Yinan; Bogorad, Roman L.; Yin, Hao; Anderson, Daniel G.; Li, Cheng; Sicinski, Piotr
• Is Part Of: Cell cycle. Volume 16:Issue 23(2017)
• Page Start: 2241
• Page End: 2248
• Publication Date: 2017-12-02
• Subjects: cyclins -- cyclin-dependent kinases -- cell cycle -- cancer -- microRNAs; Cell cycle -- Periodicals; 571.84377
• DOI: 10.1080/15384101.2017.1380132
• Languages: English
• ISSNs: 1538-4101

Abstract

ABSTRACT: By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients.