Genome‐wide association analysis of residual feed intake in Junmu No. 1 White pigs. (27th October 2017)

• Record Type: Journal Article
• Authors: Bai, C.; Pan, Y.; Wang, D.; Cai, F.; Yan, S.; Zhao, Z.; Sun, B.
• Is Part Of: Animal genetics. Volume 48:Number 6(2017)
• Page Start: 686
• Page End: 690
• Publication Date: 2017-10-27
• Subjects: feed efficiency -- immunity -- QTL -- SNP; Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.12609
• Languages: English
• ISSNs: 0268-9146

Abstract

Summary: Residual feed intake (RFI) is a measure of feed efficiency. Pigs with low RFI have reduced feed costs without compromising their growth. For marker‐assisted selection, it is helpful to identify genes or genetic markers associated with RFI in animals with improved feed efficiency at an early age. Using Illumina's PorcineSNP60 BeadChip, we performed a pilot genome‐wide association study of 217 Junmu No. 1 white male pigs phenotyped for RFI. Two‐step and one‐step methods were used separately to identify associated SNPs. Both methods obtained similar results. Twelve SNPs were identified as significantly associated with RFI at a Bonferroni adjusted P‐ level < 9.7 × 10 −7, and 204 were found to have suggestive (moderately significant) association with RFI at P < 5 × 10 −5 . NMBR, KCTD16, ASGR1, PRKCQ, PITRM1, TIAM1 and RND3 were identified as candidate genes for RFI.