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A Green Synthesis of 7‐amino‐5‐(4‐aroyl)‐1, 3‐dimethyl‐2, 4‐dioxo‐1, 2, 3, 4, 5, 8‐hexahydropyrido[2, 3‐d]pyrimidine‐6‐carbonitrile Derivatives by a One‐pot Three‐component Reaction. (22nd June 2017)
Record Type:
Journal Article
Title:
A Green Synthesis of 7‐amino‐5‐(4‐aroyl)‐1, 3‐dimethyl‐2, 4‐dioxo‐1, 2, 3, 4, 5, 8‐hexahydropyrido[2, 3‐d]pyrimidine‐6‐carbonitrile Derivatives by a One‐pot Three‐component Reaction. (22nd June 2017)
Main Title:
A Green Synthesis of 7‐amino‐5‐(4‐aroyl)‐1, 3‐dimethyl‐2, 4‐dioxo‐1, 2, 3, 4, 5, 8‐hexahydropyrido[2, 3‐d]pyrimidine‐6‐carbonitrile Derivatives by a One‐pot Three‐component Reaction
Abstract : The synthesis of polyfunctionalized 7‐amino‐5‐(4‐aroyl)‐1, 3‐dimethyl‐2, 4‐dioxo‐1, 2, 3, 4, 5, 8‐hexahydropyrido[2, 3‐ d ]pyrimidine‐6‐carbonitrile derivatives by a green approach was achieved via one‐pot three‐component reaction of arylglyoxals, malononitrile, and 1, 3‐dimethyl‐6‐aminouracil in the presence of urea as organocatalyst in EtOH:H2 O (1:1) at 60°C. This protocol provides a mild and fast procedure to structurally diverse bicyclic pyridopyrimidines in good to excellent yields. Abstract :