Partial resection of presurgical fMRI activation is associated with a postsurgical loss of language function after frontal lobe epilepsy surgery. Issue 3 (4th July 2017)

• Record Type: Journal Article
• Authors: Labudda, Kirsten; Mertens, Markus; Kalbhenn, Thilo; Schulz, Reinhard; Woermann, Friedrich G
• Is Part Of: Neurocase. Volume 23:Issue 3/4(2017)
• Page Start: 239
• Page End: 248
• Publication Date: 2017-07-04
• Subjects: Frontal lobe epilepsy -- epilepsy surgery -- language -- electrocortical stimulation -- fMRI; Neurology -- Periodicals; Neuropsychology -- Case Report; Mental Disorders -- Case Report; Nervous System Diseases -- Case Report; 616.8
• DOI: 10.1080/13554794.2017.1383445
• Languages: English
• ISSNs: 1355-4794

Abstract

ABSTRACT: We describe five patients with frontal lobe epilepsy who underwent electrocortical stimulation (ES) for language localization and language functional magnetic resonance imaging (fMRI) prior to epilepsy surgery. Six months after surgery, three patients suffered from a drop of verbal fluency. In all of them, frontal areas with presurgical language fMRI activity were resected. Our results suggest that resection in regions of areas with presurgical fMRI activation is not without risk for a postsurgical loss of function, even when ES results were negative for language function in these areas. Using fMRI activations might be specifically helpful to plan the resection when ES delivered inconclusive results.