Extracellular vesicle-mediated cell–cell communication in haematological neoplasms. (20th November 2017)

• Record Type: Journal Article
• Authors: Ohyashiki, Junko H.; Umezu, Tomohiro; Ohyashiki, Kazuma
• Is Part Of: Philosophical transactions. Volume 373:Number 1737(2018)
• Publication Date: 2017-11-20
• Subjects: extracellular vesicles -- leukaemia -- multiple myeloma -- hypoxia -- bone marrow mesenchymal stromal cells -- miRNA; Biology -- Periodicals; Science -- Periodicals; 570
• DOI: 10.1098/rstb.2016.0484
• Languages: English
• ISSNs: 0962-8436

Abstract

Abstract : Crosstalk between bone marrow tumour cells and surrounding cells, including bone marrow mesenchymal stromal cells (BM-MSCs), endothelial cells and immune cells, is important for tumour growth in haematological neoplasms. In addition to conventional signalling pathways, extracellular vesicles (EVs), which are endosome-derived vesicles containing proteins, mRNAs, lipids and miRNAs, can facilitate modulation of the bone marrow microenvironment without directly contacting non-tumourous cells. In this review, we discuss the current understanding of EV-mediated cell–cell communication in haematological neoplasms, particularly leukaemia and multiple myeloma. We highlight the actions of tumour and BM-MSC EVs in multiple myeloma. The origin of EVs, their tropism and mechanism of EV transfer are emerging issues that need to be addressed in EV-mediated cell–cell communication in haematological neoplasms. This article is part of the discussion meeting issue 'Extracellular vesicles and the tumour microenvironment'.