New 1, 1'‐Ferrocene Bis(sulfonyl) Reagents. Issue 20 (9th December 2016)

• Record Type: Journal Article
• Authors: Chanawanno, Kullapa; Holstrom, Cole; Nemykin, Victor N.; Herrick, Richard S.; Ziegler, Christopher J.
• Is Part Of: ChemistrySelect. Volume 1:Issue 20(2016)
• Page Start: 6438
• Page End: 6441
• Publication Date: 2016-12-09
• Subjects: hydroxybenzotriazole -- ferrocene -- ferrocenophane -- sulfonyl bromide -- sulfonyl hydrazide; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201601748
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Several new 1, 1'‐bis(sulfonyl)ferrocenes designed for the synthesis of sulfonamide linked biological conjugates have been prepared. 1, 1'‐Bis(sulfonylbromide)ferrocene can be produced from the corresponding sulfonylchloride via a bis(sulfonylhydrazide) intermediate. Bis(sulfonyl‐ N ‐hydroxybenzotriazole)ferrocene can also be synthesized from the sulfonyl chloride, and reaction of glycine methyl ester with the sulfonyl chloride affords a [3]ferrocenophane complex. All new compounds have been structurally characterized by X‐ray crystallography. Abstract : New 1, 1'‐bis(sulfonyl)ferrocenes designed for the synthesis of sulfonamide linked biological conjugates have been prepared. 1, 1'‐Bis(sulfonylbromide)ferrocene can be produced from the corresponding sulfonylchloride via a bis(sulfonylhydrazide) intermediate. Bis(sulfonyl‐ N ‐OBt)ferrocene can be synthesized from the sulfonyl chloride, and reaction of glycine methyl ester with the sulfonyl chloride affords a [3]ferrocenophane complex.