Iron‐catalyzed C(5)−H Imidation of Azole with N‐Fluorobenzenesulfonimide. Issue 24 (18th October 2017)

• Record Type: Journal Article
• Authors: Wang, Xiaojiao; Lei, Bowen; Ma, Lifang; Jiao, Huixuan; Xing, Wenhua; Chen, Jiaming; Li, Ziyuan
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 24(2017)
• Page Start: 4284
• Page End: 4288
• Publication Date: 2017-10-18
• Subjects: Iron-catalyzed -- Imidation -- Azole -- C5-functionalization -- N-fluorobenzenesulfonimide; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201701124
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An iron(II)‐catalyzed direct imidation of oxazole and thiazole with N ‐fluorobenzenesulfonimide (NFSI) through C(5)−H bond cleavage is disclosed, providing C5‐imidated azoles in moderate to excellent yields with broad substrate scope. This reaction represents the first iron‐catalyzed C−H imidation of arene where NFSI serves as the imidation reagent, and potentially constitutes an efficient access to C5‐functionalized azole with great medicinal significance. Abstract :