Olfactory dysfunction in the APP/PS1 transgenic mouse model of Alzheimer's disease: Morphological evaluations from the nose to the brain. Issue 6 (23rd June 2017)

• Record Type: Journal Article
• Authors: Yao, Zhi‐Gang; Hua, Fang; Zhang, Hao‐Zhuang; Li, Yan‐Yan; Qin, Ye‐Jun
• Is Part Of: Neuropathology. Volume 37:Issue 6(2017:Dec.)
• Page Start: 485
• Page End: 494
• Publication Date: 2017-06-23
• Subjects: Alzheimer's disease -- amyloid beta -- olfactory bulb -- olfactory dysfunction -- transgenic mice; Nervous system -- Diseases -- Periodicals; Nervous system -- Pathophysiology -- Periodicals; 616.8047
• DOI: 10.1111/neup.12391
• Languages: English
• ISSNs: 0919-6544

Abstract

Abstract : Olfactory dysfunction is among the signs of Alzheimer's disease (AD) and cognitive impairment. It has been demonstrated Aβ was associated with olfactory impairment observed in both transgenic mice and in AD patients. In this study, we evaluated amyloid deposition in the olfactory circuit of APP/PS1 transgenic mouse model of AD, which showed olfactory dysfunction in olfactory behavior tests. We found amyloid depositions were widely distributed in the whole olfactory circuit. Moreover, we think these amyloid depositions contribute to neuronal atrophy, dendritic abnormalities, synapse loss and axonal degeneration. Therefore, there was a correlation between olfactory deficits and amyloid deposition. Our findings provide initial insights into the pathological basis of AD‐related olfactory dysfunction.