Alterations of the translation apparatus during aging and stress response. (December 2017)

• Record Type: Journal Article
• Authors: Gonskikh, Yulia; Polacek, Norbert
• Is Part Of: Mechanisms of ageing and development. Volume 168(2017)
• Page Start: 30
• Page End: 36
• Publication Date: 2017-12
• Subjects: Ribosome -- Translation regulation -- Age-related diseases -- Non-coding RNA -- Selective translation; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2017.04.003
• Languages: English
• ISSNs: 0047-6374

Abstract

Highlights: The ribosome emerges as central regulatory hub for protein homeostasis and aging. Alterations of the translation machinery affect the rate and accuracy of translation. Attenuated translation rates and lifespan extension appear to correlate. Selective translation of specific mRNAs during aging counteract cellular damage. Abstract: Aging is a biological process characterized by the irreversible and time-dependent deterioration of cell functions, tissues, and organs. Accumulating studies in a wide range of species from yeast to human revealed changes associated with the aging process to be conserved throughout evolution. The main characteristics of aging are (i) genomic instability, (ii) loss of telomere function, (iii) epigenetic changes, (iv) increased cellular senescence, (v) depletion of the stem cell pool, (vi) altered intercellular communication and (vii) loss of protein homeostasis. Among the multiple molecular mechanisms underlying aging, alterations of the translation machinery affecting the rate and selectivity of protein biosynthesis seem to play a central role. At the very heart of translation is the ribosome, a multifaceted and universally conserved RNA-protein particle responsible for accurate polypeptide synthesis and co-translational protein folding. Here we summarize and discuss recent developments on the contribution of altered translation and age-dependent modifications on the ribosome structure to aging and cellular senescence.