Cell Migration: Surface Curvature Differentially Regulates Stem Cell Migration and Differentiation via Altered Attachment Morphology and Nuclear Deformation (Adv. Sci. 2/2017). Issue 2 (February 2017)

• Record Type: Journal Article
• Authors: Werner, Maike; Blanquer, Sébastien B. G.; Haimi, Suvi P.; Korus, Gabriela; Dunlop, John W. C.; Duda, Georg N.; Grijpma, Dirk. W.; Petersen, Ansgar
• Is Part Of: Advanced science. Volume 4:Issue 2(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02
• Subjects: 3D surface curvature -- cell migration -- nuclear mechanics -- osteogenic differentiation -- stereolithography; Science -- Periodicals; 505
• DOI: 10.1002/advs.201770007
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : Mesenchymal stem cells, harvested from the bone marrow, alter their behavior depending on the local curvature of the 3D‐printed surfaces they are seeded upon, as described by Ansgar Petersen and co‐workers in article number 1600347. While concave surfaces promote stem cell migration, convex surfaces enhance cell specification into bone cells, a process driven by curvature‐dependent forces on the cell's nucleus.