Phenotypic differences between familial versus non-familial Juvenile onset open angle glaucoma patients. (2nd January 2018) - Gupta, Viney
ABSTRACT: Aim: To evaluate phenotypic differences among familial and non-familial JOAG patients. Methods: First degree relatives of unrelated JOAG patients were screened for glaucoma and ocular hypertension. JOAG probands were grouped as familial or non-familial and phenotypic differences in terms of age of onset, gender, baseline untreated IOP, presence angle dysgenesis, and refractive error was compared between the two groups. Results: Out of 368 unrelated JOAG patients, 134 in whom all first degree relatives had been examined were included in the study. The non-familial JOAG ( n = 96) had similar age of onset as familial JOAG ( n = 38); ( p = 0.076) but had greater male preponderance ( p = 0.046), and had the higher baseline IOP ( p = 0.044) compared to familial JOAG. However, on adjustment using the Bonferroni correction, the observed differences were not found to be significant. Both groups had similar proportion of patients with angle dysgenesis ( p = 0.46) and high myopia ( p = 0.72). Conclusions: Non-familial JOAG were not found to be phenotypically different from the familial JOAG patients in this cohort.