Blood pressure evolution in young patients with acute ischemic stroke: a new model for understanding the natural course of spontaneous hypertension?. (1st February 2018)

• Record Type: Journal Article
• Authors: Bonardo, Pablo; Pantiu, Fatima; Chertcoff, Anibal; León Cejas, Luciana; Pacha, Sol; Uribe Roca, Claudia; Ernst, Glenda; Fernández Pardal, Manuel; Reisin, Ricardo
• Is Part Of: International journal of neuroscience. Volume 128:Number 2(2018)
• Page Start: 140
• Page End: 145
• Publication Date: 2018-02-01
• Subjects: Hypertension -- acute stroke -- young patients -- blood pressure -- ischemic stroke; Nervous system -- Periodicals; 612.805
• DOI: 10.1080/00207454.2017.1378198
• Languages: English
• ISSNs: 0020-7454

Abstract

ABSTRACT: Background: Approximately 80% of patients suffering an acute ischemic stroke develop transient hypertension. The physiopathological mechanism remains unclear. Due to the lack of vascular risk factors, young adults could be a useful model for understanding blood pressure (BP) evolution in this setting. Methods: Patients between 18 and 55 years old admitted with an acute ischemic stroke were included. BP was evaluated during the following 48 h. Hypertension was defined as: systolic blood pressure (SBP) ≥140 mmHg or diastolic blood pressure (DBP) ≥90 mmHg. Patients were divided into two groups: RF group included those who had a previous vascular risk factor and/or other medical condition known to affect the autonomic function; noRF group included patients without any of the previously stated conditions. Results: Thirty-nine patients were included: mean age: 44.26 years old, 21 were males (53.8%). Mean SBP and DBP at admission were 139.77 ± 5.35 mmHg (range: 90–243) and 84.44 ± 3.02 mmHg (range: 60–128), respectively; 43.58% patients were hypertensive at admission. SBP decreased significantly during the first 48 h ( p = 0.044) for the entire population. RF group has higher SBP ( p = 0.009) and DBP ( p = 0.011) at admission than the noRF group. Conclusion: Most patients were normotensive at admission and BP fell spontaneously despite BP at admission. Young patients without medical conditions that could alter the autonomic system function could be a useful model for understanding acute hypertension in ischemic stroke.