2-(1-Methylhydrazinyl)pyridine as a reductively removable directing group in a cobalt-catalyzed C(sp2)–H bond alkenylation/annulation cascade. Issue 1 (6th December 2017)

• Record Type: Journal Article
• Authors: Zhai, Shengxian; Qiu, Shuxian; Chen, Xiaoming; Wu, Jiang; Zhao, Hua; Tao, Cheng; Li, Yun; Cheng, Bin; Wang, Huifei; Zhai, Hongbin
• Is Part Of: Chemical communications. Volume 54:Issue 1(2018)
• Page Start: 98
• Page End: 101
• Publication Date: 2017-12-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc08533h
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new application of 2-(1-methylhydrazinyl)pyridine as a reductively bidentate directing group to directing cobalt-catalyzed C(sp 2 )–H alkenylation/annulation to form isoquinoline backbones. Abstract : We describe a new application of 2-(1-methylhydrazinyl)pyridine as a bidentate directing group to directing cobalt-catalyzed C(sp 2 )–H alkenylation/annulation of the corresponding benzoic hydrazides to form an isoquinoline backbone, via reacting with a terminal or internal alkyne followed by annulation. The reaction shows a broad substrate scope with the products obtained in good to excellent yields and high regioselectivity. Moreover, the directing group can be reductively removed in one step under mild conditions.