New Obesity Indices and Adipokines in Normotensive Patients and Patients With Hypertension: Comparative Pilot Analysis. (April 2014)

• Record Type: Journal Article
• Authors: Stępień, Mariusz; Stępień, Anna; Banach, Maciej; Wlazeł, Rafał N.; Paradowski, Marek; Rizzo, Manfredi; Toth, Peter P.; Rysz, Jacek
• Is Part Of: Angiology. Volume 65:Number 4(2014)
• Page Start: 333
• Page End: 342
• Publication Date: 2014-04
• Subjects: obesity -- hypertension -- adipokines -- obesity indices; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319713485807
• Languages: English
• ISSNs: 0003-3197

Abstract

We compared the obesity parameters and selected adipokines—leptin, adiponectin, and resistin—in obese patients with hypertension and normotensive patients. A total of 67 nondiabetic obese outpatients were divided into 2 groups: A–hypertensive and B–normotensive. Serum levels of leptin, adiponectin, resistin, and insulin were measured. Weight, height, waist circumference, and hip circumference were measured to calculate waist-to-hip ratio (WHR), weight-to-height ratio, visceral adiposity index, and body adiposity index (BAI). Among patients with hypertension, significant positive correlations were observed between leptin and body mass index and BAI ( r = .31 and r = .63, respectively). In normotensive patients, leptin positively correlated with BAI ( r = .73, P < .01) and negatively with WHR ( r = −.55, P < .0001); adiponectin negatively correlated with WHR ( r = .38, P < .01) and BAI ( r = .52; P < .0001), and resistin negatively correlated with WHR ( r = −.36, P < .05). In conclusion, visceral obesity and leptin are associated with hypertension in obese patients.