Comparison of 22-gauge standard fine needle versus core biopsy needle for endoscopic ultrasound-guided sampling of suspected pancreatic cancer: a randomized crossover trial. (2nd January 2018)

• Record Type: Journal Article
• Authors: Noh, Dong Hyo; Choi, Kyu; Gu, Seonhye; Cho, Juhee; Jang, Kee-Taek; Woo, Young Sik; Lee, Kyu Taek; Lee, Jong Kyun; Lee, Kwang Hyuck
• Is Part Of: Scandinavian journal of gastroenterology. Volume 53:Number 1(2018)
• Page Start: 94
• Page End: 99
• Publication Date: 2018-01-02
• Subjects: Endoscopic ultrasound -- fine-needle aspiration -- fine-needle biopsy -- pancreatic cancer -- diagnostic accuracy; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.1080/00365521.2017.1390597
• Languages: English
• ISSNs: 0036-5521

Abstract

Abstract: Background: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is effective for tissue diagnosis of pancreatic mass. To improve diagnostic yield and drawbacks, 22-gauge (G) core biopsy (FNB) needle has been developed. This study aims to compare 22G FNA and FNB needles for EUS-guided sampling of suspected pancreatic cancer. Methods: This is a randomized controlled crossover trial. A total of 60 patients with suspected unresectable pancreatic cancer referred for EUS-guided sampling were randomly assigned to two groups. Both groups had 22G FNA and FNB needles performed in a randomized order. The primary endpoint was the cytological, histological and overall diagnostic accuracy of pancreatic cancer. Results: FNA and FNB needles reported similar level of diagnostic accuracy (FNA needle 95% vs. FNB needle 93.3%; p = .564), and it was not statistically different. However, cytological cellularity was significantly higher in the FNB needles compared to FNA needles (odds ratio 2.75, 95% confidence interval (CI)). There were no procedure-related complications in both needles. Conclusions: The diagnostic accuracy of EUS-guided sampling for pancreatic cancer using 22G FNA is comparable to FNB needles. The cytological quality of specimen is better in the FNB needle.