Asymmetric synthesis of 3-aminodihydrocoumarins via the chiral guanidine catalyzed cascade reaction of azlactones. Issue 1 (26th September 2017)

• Record Type: Journal Article
• Authors: Ruan, Sai; Lin, Xiaobin; Xie, Lihua; Lin, Lili; Feng, Xiaoming; Liu, Xiaohua
• Is Part Of: Organic chemistry frontiers. Volume 5:Issue 1(2018)
• Page Start: 32
• Page End: 35
• Publication Date: 2017-09-26
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c7qo00768j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A new asymmetric preparative method of 3-aminodihydrocoumarins via reactions of azlactones and 2-nitrovinylphenols using chiral bifunctional guanidine catalysts. Abstract : A highly efficient bifunctional guanidine catalyst was developed for the asymmetric cascade reaction between 2-nitrovinylphenols and azlactones. A wide variety of 3-aminodihydrocoumarin derivatives could be obtained in high yields (up to 99% yield) with excellent enantioselectivities (up to 99% ee) and diastereoselectivities (>19 : 1 dr).