A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea. Issue 6 (19th March 2018)

• Record Type: Journal Article
• Authors: Cretton, Sylvian; Oyarzún, Alejandra; Righi, Davide; Sahib, Lamia; Kaiser, Marcel; Christen, Philippe; Fajardo, Victor
• Is Part Of: Natural product research. Volume 32:Issue 6(2018)
• Page Start: 695
• Page End: 701
• Publication Date: 2018-03-19
• Subjects: Gavilea lutea -- bibenzyls -- gavilein -- antifungal activity -- antiprotozoal activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1338287
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new bibenzyl derivative (4 ), together with two glycosylated flavonoids (1 and2 ), batatasin III (3 ) and the phenanthrene isohircinol (5 ) were isolated from the aerial parts of Gavilea lutea . Their structures were elucidated on the basis of spectroscopic studies including 1D and 2D NMR, UV, IR and HRESIMS. All isolated compounds were evaluated for their antifungal activity towards Candida albicans . The new compound4 showed inhibitory activity with a MIQ of 50 μg. In addition, compound4 exhibited a selective activity (IC50 = 2.3 μg/mL) against Leishmania donovani . Abstract :