Cytotoxic withanolides from Physalis angulata. Issue 6 (19th March 2018)

• Record Type: Journal Article
• Authors: Gao, Caiyun; Li, Ruijun; Zhou, Miaomiao; Yang, Yanwei; Kong, Lingyi; Luo, Jun
• Is Part Of: Natural product research. Volume 32:Issue 6(2018)
• Page Start: 676
• Page End: 681
• Publication Date: 2018-03-19
• Subjects: Withanolides -- Physalis angulata L -- Cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1338281
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new withanolide (1 ), physagulide P, together with five known withanolides (2–6 ), was isolated from the aerial parts of Physalis angulata L. The structure of new compound was elucidated on the basis of extensive spectroscopic techniques, including 1D, 2D NMR and HRESIMS. The activity screening indicated that compound1 showed significant cytotoxicities against the human osteosarcoma cell line MG-63, HepG-2 hepatoma cells and breast cancer cells MDA-MB-231 with the IC50 value of 3.50, 4.22 and 15.74 μM. Abstract :