Neuropsychiatric Symptoms and Regional Neocortical Atrophy in Mild Cognitive Impairment and Alzheimer's Disease. (March 2014)

• Record Type: Journal Article
• Authors: Rafii, Michael S.; Taylor, Curtis S.; Kim, Hyun T.; Desikan, Rahul S.; Fleisher, Adam S.; Katibian, David; Brewer, James B.; Dale, Anders M.; Aisen, Paul S.
• Is Part Of: American journal of Alzheimer's disease & other dementias. Volume 29:Number 2(2014)
• Page Start: 159
• Page End: 165
• Publication Date: 2014-03
• Subjects: psychosis -- dementia -- Alzheimer's disease -- neuroimaging; Alzheimer's disease -- Periodicals; Dementia -- Periodicals; Alzheimer's disease -- Patients -- Care -- United States -- Periodicals; 616.83
• DOI: 10.1177/1533317513507373
• Languages: English
• ISSNs: 1533-3175

Abstract

Background: To assess the relationship between regional neocortical atrophy and psychotic symptoms in adults with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Methods: Rates of change in regional neocortical atrophy as measured by longitudinal magnetic resonance imaging scans and the occurrence of psychotic symptoms and/or the long-term use of antipsychotic medications in 389 outpatients with MCI or AD in Alzheimer's Disease Neuroimaging Initiative. Results: Atrophy rate of 3 specific neocortical regions, lateral frontal, lateral parietal, and anterior cingulate gyrus, was significantly associated with the onset of psychosis including delusions, agitation, wandering, and hallucinations and/or the need for chronic antipsychotic medications. Atrophy rate of the lateral frontal lobe correlated most significantly with onset of psychotic symptoms or need for chronic antipsychotic medications. Conclusions: Psychosis was associated with volume loss in specific regions of the lateral frontal and parietal lobes as well as anterior cingulate gyrus.