Reproducibility of manual and semi-automated late enhancement quantification in patients with Fabry disease. (March 2014)

• Record Type: Journal Article
• Authors: Machann, Wolfram; Geier, Oliver; Koeppe, Sabrina; O'Donnell, Thomas; Greiser, Andreas; Breunig, Frank; Sandstede, Joern; Hahn, Dietbert; Koestler, Herbert; Beer, Meinrad
• Is Part Of: Acta radiologica. Volume 55:Number 2(2014:Mar.)
• Page Start: 155
• Page End: 160
• Publication Date: 2014-03
• Subjects: Cardiomyopathy -- late enhancement -- reproducibility -- quantification; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185113505275
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: Late enhancement (LE) imaging is increasingly used for diagnosis of non-ischemic cardiomyopathy. However, the mostly patchy appearance of LE in this context may reduce the reproducibility of LE measurement. Purpose: To report intra- and inter-observer variabilities of LE measurements in Fabry disease using manual and semi-automated quantification. Material and Methods: Twenty MRI data-sets of male patients aged 44 ± 7 years were analyzed twice (interval 12 months) by one observer and additionally once by a second observer. Left ventricular (LV) parameters were determined using cine MRI. Gradient-echo LE images were analyzed by manual planimetry and by a semi-automatic prototype software. Variabilities were determined by Bland-Altman analyses and additionally intra-class correlation coefficient (ICC) values were calculated to survey intra- and inter-observer reproducibility. Results: The amount of LE was 5.2 ± 5.1 mL or 2.8 ± 2.6 % of LV mass (observer 2). LE was detected predominantly intramurally in a patchy pattern. All patients had LE restricted to the basal infero-lateral parts of the LV. The extent of LE correlated to LV mass (207 ± 70 g, P < 0.05, r = 0.6). The intra- and inter-observer variabilities were −0.6 to 1.0 mL and −0.7 to 1.6 mL, respectively (95% confidence intervals). ICC values were 0.981–0.999. The semi-automatic software allowed quantification of LE areas in all patients. The comparison of LE amount determined by semi-automatic software versus manual planimetry yielded an intra-observer variability ranging from −1.9 to 2.3 mL. Conclusion: Semi-automatic planimetry of patchy LE in patients with Fabry disease is feasible. The determined intra- and inter-observer variabilities for manual and semi-automatic planimetry were in the range of 20–40% of LE amount with high ICC values.