Diagnosis of intracranial hemorrhagic lesions: comparison between 3D-SWAN (3D T2*-weighted imaging with multi-echo acquisition) and 2D-T2*-weighted imaging. (March 2014)

• Record Type: Journal Article
• Authors: Hayashida, Yoshiko; Kakeda, Shingo; Hiai, Yasuhiro; Ide, Satoshi; Ogasawara, Atsushi; Ooki, Hodaka; Watanabe, Keita; Nishimura, Joji; Ohnari, Norihiro; Korogi, Yukunori
• Is Part Of: Acta radiologica. Volume 55:Number 2(2014:Mar.)
• Page Start: 201
• Page End: 207
• Publication Date: 2014-03
• Subjects: CNS -- hemorrhage -- imaging sequences -- MR imaging; Radiology, Medical -- Periodicals; Radiography, Medical -- Periodicals; Radiotherapy -- Periodicals; 616.0757
• DOI: 10.1177/0284185113495836
• Languages: English
• ISSNs: 0284-1851

Abstract

Background: 3D-susceptibility-weighted angiography (SWAN) can produce high-resolution images that yield excellent susceptibility-weighted contrast at a relatively short acquisition time. Purpose: To compare SWAN- and 2D-T2*-weighted gradient-echo images (T2*-WI) for their sensitivity in the depiction of cerebral hemorrhagic lesions. Material and Methods: We subjected 75 patients with suspected cerebral hemorrhagic lesions to SWAN and T2*-WI at 3T. We first measured the contrast-to-noise ratio (CNR) using an agar phantom that contained different concentrations of superparamagnetic iron oxide (SPIO). The acquisition time for SWAN and T2*-WI was similar (182 vs. 196 s). Neuroradiologists compared the two imaging methods for lesion detectability and conspicuity. Results: The CNR of the phantom was higher on SWAN images. Of the 75 patients, 50 were found to have a total of 278 cerebral hemorrhagic lesions (microbleeds, n = 229 [82.4%]; intracerebral hemorrhage, n = 18 [6.5%]; superficial siderosis, n = 13 [4.7%]; axonal injuries, n = 8 [2.9%]; subarachnoid hemorrhage [SAH] or brain contusion, n = 3 each [1.0%]; subdural hematoma, n = 2 [0.7%]; cavernous hemangioma or dural arterteriovenous fistula, n = 1 each [0.4%]). In none of the lesions was the SWAN sequence inferior to T2*-WI with respect to lesion detectability and conspicuity. In fact, SWAN yielded better lesion conspicuity in patients with superficial siderosis and SAH: it detected significantly more lesions than T2*-WI ( P < 0.01) and it was particularly useful for the detection of microbleeds and lesions near the skull base. Conclusion: SWAN is equal or superior to standard T2*-WI for the diagnosis of various cerebral hemorrhagic lesions. Because its acquisition time is reasonable it may replace T2*-WI.