New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota. (2nd November 2017)

• Record Type: Journal Article
• Authors: Lee, Heetae; Ko, GwangPyo
• Is Part Of: Gut microbes. Volume 8:Isuse 6(2017)
• Page Start: 616
• Page End: 620
• Publication Date: 2017-11-02
• Subjects: gut microbiome -- IFN-β -- Lactobacillus -- norovirus -- vitamin A; Gastrointestinal system -- Microbiology -- Periodicals; Microbiology -- Periodicals; Intestine, Small -- Periodicals; 616.3
• DOI: 10.1080/19490976.2017.1353842
• Languages: English
• ISSNs: 1949-0984

Abstract

ABSTRACT: Gut microbiota has been revealed to play an important role in various health conditions, and recent studies have suggested the modulation of gut microbiota as a therapeutic strategy. There is no effective treatment of norovirus infection, though vitamin A has been suggested to have an antiviral effect in an epidemiological study. We demonstrated that vitamin A significantly inhibited murine norovirus replication. Vitamin A supplementation significantly increased the abundance of Lactobacillus sp. during norovirus infection, which played a crucial role in antiviral efficacy, inhibiting murine norovirus. Therefore, we elaborated the antiviral effect of vitamin A via modulation of gut microbiota. Furthermore, we suggest a novel strategy, using potential probiotics, as having a protective and therapeutic effect on noroviral infection.