Front Cover: Characterization of Terminators in Saccharomyces cerevisiae and an Exploration of Factors Affecting Their Strength (ChemBioChem 24/2017). (4th December 2017)

• Record Type: Journal Article
• Authors: Wei, Linna; Wang, Zhaoxia; Zhang, Genlin; Ye, Bangce
• Is Part Of: Chembiochem. Volume 18:Number 24(2017)
• Page Start: 2366
• Page End: 2366
• Publication Date: 2017-12-04
• Subjects: fluorescence -- gene expression -- metabolic engineering -- proteins -- RNA -- terminators; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201700617
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The front cover picture shows the transcription process in the nucleus of yeast and the translation process in the cytoplasm. The area with the blue background represents the nucleus and nucleopore on the nuclear envelope. We describe the termination principle of the yeast terminator in the nucleus: a hairpin structure (red) formed at the transcription level causes the RNA polymerase (blue ellipse) to fall off the DNA template. The green section shows the translation process of the gene in the cytoplasm. The tripolymer represents mRNA that is being translated, with the new protein emerging. The expression level of the protein can characterize the regulatory role of the yeast terminator. More information can be found in the full paper by G. Zhang et al. onpage 2422 in Issue 24, 2017 (DOI:10.1002/cbic.201700516 ).