A new diarylheptanoid from Alpinia officinarum promotes the differentiation of 3T3-L1 preadipocytes. Issue 5 (4th March 2018)

• Record Type: Journal Article
• Authors: Zhang, Xuguang; Zhang, Xiaopo; Wang, Yong; Chen, Feng; Li, Youbin; Li, Yonghui; Tan, Yinfeng; Gong, Jingwen; Zhong, Xia; Li, Hailong; Zhang, Junqing
• Is Part Of: Natural product research. Volume 32:Issue 5(2018)
• Page Start: 529
• Page End: 535
• Publication Date: 2018-03-04
• Subjects: Alpinia officinarum Hance -- diarylheptanoid -- 3T3-L1 preadipocytes -- differentiation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1327858
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new diarylheptanoid, namely trans -(4 R, 5 S )-epoxy-1, 7-diphenyl-3-heptanone (1 ), and a new natural product, 7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-hepta-4 E, 6 E -dien-3-one (2 ), were obtained from the aqueous extract of Alpinia officinarum Hance, together with three other diarylheptanoids, 5-hydroxy-1, 7-diphenyl-3-heptanone (3), 1, 7-diphenyl-4E-en-3-heptanone (4) and 5-methoxy-1, 7-diphenyl-3-heptanone (5). The structures were characterised mainly by analysing their physical data including IR, NMR and HRMS. This study highlights that the 4, 5-epoxy moiety in1 is rarely seen in diarylheptanoids. In addition, the five isolates were tested for their differentiation activity of 3T3-L1 preadipocytes. The results showed that these compounds could dose-dependently promote adipocyte differentiation without cytotoxicity (IC50 > 100 μM). Abstract :