Cu(I)-phosphine complex: An efficient catalyst for synthesis of 3-indole derivatives through one-pot MCR under mild conditions. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Prasad, Avvari N.; Braga, Felipe C.; Lopes, Rosângela da S.; Casagrande, Gleison A.; de Lima, Dênis P.; Beatriz, Adilson
• Is Part Of: Synthetic communications. Volume 48:Issue 1(2018)
• Page Start: 104
• Page End: 114
• Publication Date: 2018-01-02
• Subjects: 3-Substituted indoles -- Cu-catalysis -- multicomponent reaction -- water -- Yonemitsu condensation; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2017.1394467
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: An efficient copper (I) halotriphenylphosphine catalyzed one-pot multicomponent reaction (MCR) of 3-substituted indole derivatives has been developed using a variety of aldehydes (aromatic, aliphatic, and heteroaromatic), indole, and active methylene substrates such as malononitrile and ethyl 2-cyano acetate. This reaction proceeds smoothly and obtained good to excellent yields (68–93%) using water as green solvent under ambient conditions. The obtained products were confirmed by 1 H, 13 C NMR, and mass spectroscopy techniques. The one-pot MCR occurs through formation of Knoevenagel adducts then followed by Michael addition of indole. GRAPHICAL ABSTRACT: