The killer cell lectin‐like receptor B1 (KLRB1) 503T>C polymorphism (rs1135816) and acute rejection after liver transplantation. (25th December 2017)

• Record Type: Journal Article
• Authors: Thude, H.; Rother, S.; Sterneck, M.; Klempnauer, J.; Nashan, B.; Schwinzer, R.; Koch, M.
• Is Part Of: HLA. Volume 91:Number 1(2018)
• Page Start: 52
• Page End: 55
• Publication Date: 2017-12-25
• Subjects: acute rejection -- CD161 -- killer cell lectin‐like receptor B1 -- liver transplantation; Immunogenetics -- Periodicals; Antigens -- Periodicals; HLA histocompatibility antigens -- Periodicals; 571.9645
• DOI: 10.1111/tan.13172
• Languages: English
• ISSNs: 2059-2302

Abstract

Abstract : The killer cell lectin‐like receptor B1 (KLRB1) gene encodes for CD161 expressed by different subsets of leukocytes involved in the development of acute liver transplant rejection. The single nucleotide polymorphism (SNP) 503T>C (rs1135816) in the KLRB1 gene represents a missense mutation modifying functional properties of CD161. The aim of our study is to determine whether the SNP 503T>C is associated with acute liver transplant rejection. We genotyped the SNP for 163 liver recipients without acute rejection, 125 recipients with a single acute rejection, and 53 recipients with multiple acute rejections. The genotype frequencies within the groups did not show any significant difference. Our data suggest that the SNP 503T>C has no impact on the susceptibility of acute liver transplant rejection.