Two Novel SNPs of PPARγ Significantly Affect Weaning Growth Traits of Nanyang Cattle. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Huang, Jieping; Chen, Ningbo; Li, Xin; An, Shanshan; Zhao, Minghui; Sun, Taihong; Hao, Ruijie; Ma, Yun
• Is Part Of: Animal biotechnology. Volume 29:Issue 1(2018)
• Page Start: 68
• Page End: 74
• Publication Date: 2018-01-02
• Subjects: Association analysis -- cattle -- growth traits -- PPARγ; Animal biotechnology -- Periodicals; Animals, Domestic -- genetics -- Periodicals; Animals, Genetically Modified -- Periodicals; 660.6
• DOI: 10.1080/10495398.2017.1304950
• Languages: English
• ISSNs: 1049-5398

Abstract

ABSTRACT: Peroxisome-proliferator-activated receptor gamma ( PPARγ ) is a key transcription factor that controls adipocyte differentiation and energy in mammals. Therefore, PPARγ is a potential factor influencing animal growth traits. This study primarily evaluates PPARγ as candidate gene for growth traits of cattle and identifies potential molecular marker for cattle breeding. Per previous studies, PPARγ mRNA was mainly expressed at extremely high levels in adipose tissues as shown by quantitative real-time polymerase chain reaction analysis. Three novel SNPs of the bovine PPARγ gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7. The present study also investigated genetic characteristics of these SNP loci in six populations. Association analysis showed that SNP1 and SNP3 loci significantly affect weaning growth traits, especially body weight of Nanyang cattle. These results revealed that SNP1 and SNP3 are potential molecular markers for cattle breeding.