A lesson for site-selective C–H functionalization on 2-pyridones: radical, organometallic, directing group and steric controls. Issue 1 (8th December 2017)

• Record Type: Journal Article
• Authors: Hirano, Koji; Miura, Masahiro
• Is Part Of: Chemical science. Volume 9:Issue 1(2018)
• Page Start: 22
• Page End: 32
• Publication Date: 2017-12-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7sc04509c
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : This minireview focuses on recent advances in site-selective C–H functionalization on 2-pyridone which is an important heterocyclic motif in medicinal and pharmaceutical chemistry. Abstract : A 2-pyridone ring is a frequently occurring subunit in natural products, biologically active compounds, and pharmaceutical targets. Thus, the selective synthesis of substituted 2-pyridone derivatives through decoration and/or formation of pyridone rings has been one of the important longstanding subjects in organic synthetic chemistry. This minireview focuses on recent advances in site-selective C–H functionalization on 2-pyridone. The reported procedures are categorized according to the site selectivity that is achieved, and the substrate scope, limitations, mechanism, and controlling factors are briefly summarized.