Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a, l]pyrene in oral tissues of mice. (2nd October 2017)

• Record Type: Journal Article
• Authors: Chen, Kun-Ming; Schell, Todd D.; Richie, John P.; Sun, Yuan-Wan; Zhang, Shang-Min; Calcagnotto, Ana; Aliaga, Cesar; Gowda, Krishne; Amin, Shantu; El-Bayoumy, Karam
• Is Part Of: Journal of environmental science and health. Volume 35:Number 4(2017)
• Page Start: 213
• Page End: 222
• Publication Date: 2017-10-02
• Subjects: Alcohol -- DB[a, l]P -- oral cancer -- DNA adduct -- immune regulation; Carcinogenesis -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmentally induced diseases -- Periodicals; Environmental Health -- periodicals; Carcinogens, Environmental -- periodicals; Hazardous Substances -- periodicals; 616.994071
• DOI: 10.1080/10590501.2017.1391514
• Languages: English
• ISSNs: 1059-0501

Abstract

ABSTRACT : Previously, we showed that oral application of the environmental pollutant dibenzo[ a, l ]pyrene (DB[ a, l ]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[ a, l ]P-induced DNA damage and immune regulation; we showed that alcohol (6.4% v/v in the diet, 35% of Calories) significantly enhanced the levels of (−)- anti - trans -DB[ a, l ]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[ a, l ]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[ a, l ]P.