A study on the polymorphisms of the renin–angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria. (March 2014)

• Record Type: Journal Article
• Authors: Meroufel, Djabaria Naïma; Médiène-Benchekor, Sounnia; Dumont, Julie; Benhamamouch, Soraya; Amouyel, Philippe; Brousseau, Thierry
• Is Part Of: Journal of the renin-angiotensin-aldosterone system. Volume 15:Number 1(2014:Mar.)
• Page Start: 1
• Page End: 6
• Publication Date: 2014-03
• Subjects: Angiotensin II type 1 receptor -- angiotensin-converting enzyme -- angiotensinogen -- polymorphisms -- genetic epidemiology -- Algerian population; Renin-angiotensin system -- Periodicals; 616.132
• DOI: 10.1177/1470320313485898
• Languages: English
• ISSNs: 1470-3203

Abstract

Introduction: Several studies have assessed the relationship between blood pressure (BP) and polymorphisms within the genes encoding angiotensinogen ( AGT ), angiotensin II type 1 receptor ( AT1R ) and angiotensin-converting enzyme ( ACE ). However, considering the relatively large discrepancy in frequency and impact of these variants between ethnic groups and populations, still unavailable data from Algerian population are needed. Objective: Our purpose is to evaluate the association between the AGT M235T, AT1R +1166A/C and ACE I/D polymorphisms and variations in systolic (SBP), diastolic (DBP) and pulse pressure (PP) values. Methods: The associations with BP were assessed in a representative sample of 115 male subjects free of coronary heart disease (CHD). The AGT M235T, AT1R +1166A/C and ACE I/D polymorphisms were determined by PCR-ASO and PCR-RFLP analysis, respectively. Results: We showed no associations between the AGT M235T, AT1R + 1166A/C nor the ACE I/D polymorphisms with variations in BP values. However, concerning the ACE I/D polymorphism, subjects carrying the ACE I allele tended to have higher SBP (+4.1 mmHg) and PP values (+3.2 mmHg) than DD subjects (adjusted p = 0.087 and p = 0.102, respectively). Conclusion: The ACE I/D polymorphism needs further investigation in a larger Algerian study, especially concerning its putative impact on SBP and PP.