Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable. (March 2018)

• Record Type: Journal Article
• Authors: Zhang, Weidong; Zhao, Yong; Zhang, Pengfei; Hao, Yanan; Yu, Shuai; Min, Lingjiang; Li, Lan; Ma, Dongxue; Chen, Liang; Yi, Bao; Tang, Xiangfang; Meng, Qingshi; Liu, Lei; Wang, Shukun; Shen, Wei; Zhang, Hongfu
• Is Part Of: Chemosphere. Volume 194(2018)
• Page Start: 147
• Page End: 157
• Publication Date: 2018-03
• Subjects: Male fertility -- Spermatogenesis -- H2S -- NH3 -- Heritance; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2017.11.164
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Numerous epidemiological studies suggest that air pollutants cause a decline in the quality of human spermatozoa and thus a reduction in fertility. However, the exact cause of infertility remains unknown. Air pollution gases, such as NH3 and H2 S are either free or bound to airborne particular materials (PM) and are abundant and reactive. The aim of this current investigation was to explore the impacts of NH3 and/or H2 S on male fertility and the underlying mechanisms. Male mouse exposed to H2 S and/or NH3 and after two generations were used to evaluate the impacts on fertility. The fertility, and spermatozoa quality parameters and proteins involved in spermatogenesis were investigated. Our current investigation demonstrates: i) H2 S and/or NH3 decrease male fertility by 20–30%, reduce the spermatozoa concentration about 20–40%, decrease 10–20%, increase around 30%; ii) the reduction in male fertility by H2 S and/or NH3 can be inheritable; iii) H2 S and/or NH3 can diminish male fertility through the disruption of spermatogenesis without affecting other body parameters such as body weight and organ index. One component of air pollutants, for example NH3, does not have a severe impact; however, two or more pollutants such as H2 S and NH3 combined can cause serious health problems, especially with regard to male fertility. We suggest that greater attention should be paid to these air pollutants to improve human health and fertility. Graphical abstract: Highlights: NH3 and/or H2 S decrease male fertility. The reduction in male fertility by NH3 and/or H2 S can be inheritable. NH3 and/or H2 S diminish male fertility through the disruption of spermatogenesis.