Pathology of liver tumours. Issue 12 (December 2017)

• Record Type: Journal Article
• Authors: Cain, Owen L.; Brown, Rachel M.
• Is Part Of: Surgery. Volume 35:Issue 12(2017)
• Page Start: 667
• Page End: 674
• Publication Date: 2017-12
• Subjects: Cholangiocarcinoma -- focal nodular hyperplasia -- hepatocellular adenoma -- hepatocellular carcinoma -- liver pathology; Surgery -- Periodicals; Surgery -- Periodicals; Chirurgie -- Périodiques; Thérapeutique -- Périodiques; Electronic journals; 617
• DOI: 10.1016/j.mpsur.2017.09.006
• Languages: English
• ISSNs: 0263-9319

Abstract

Abstract: Histopathological assessment of liver tissue is essential for the management of patients with a whole range of liver tumours. Biopsies are often helpful in establishing the initial diagnosis of a lesion. Intraoperative frozen sections can provide the surgeon with valuable information regarding the nature of a liver lesion and/or the clearance of surgical margins. Examination of tissue from resection and transplant operations is important in confirming the preoperative diagnosis and for providing additional prognostic information. This article outlines the pathway for the processing of liver tumour tissue in the histopathology laboratory, before discussing the pathological features of the more commonly encountered benign and malignant liver tumours. Included within this discussion are epithelial tumours of both hepatocellular and biliary derivation, mesenchymal lesions and metastatic liver lesions. The age of the patient and the presence or absence of background liver disease are major determinants of the likely differential diagnosis of a liver lesion. The article also summarizes the key data items included in a histopathology report for surgical excision specimens.