Association between physical activity and inflammatory bowel disease risk: A meta-analysis. Issue 12 (December 2016)

• Record Type: Journal Article
• Authors: Wang, Qiang; Xu, Ke-Qun; Qin, Xiang-Rong; Wen-Lu, ; Yan-Liu, ; Wang, Xiao-Yong
• Is Part Of: Digestive and liver disease. Volume 48:Issue 12(2016)
• Page Start: 1425
• Page End: 1431
• Publication Date: 2016-12
• Subjects: Crohn's disease -- Inflammatory bowel disease -- Meta-analysis -- Physical activity -- Ulcerative colitis; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2016.08.129
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background: Previous studies of an association between physical activity and inflammatory bowel disease have yielded conflicting results. Aim: This meta-analysis was conducted to clarify whether there is an association between physical activity and inflammatory bowel disease. Methods: The PubMed and Web of Science databases were searched for relevant studies published up to October 2015. Data were extracted and the summary relative risks (RRs) were calculated using a random effects or a fixed-effects model, according to heterogeneity. Results: Seven studies were included in the analysis. Relative to individuals with low physical activity, those who participated in high physical activity had an RR of 0.63 (95% CI, 0.50–0.79) for developing Crohn's disease. In stratified analyses, a significantly lower risk for Crohn's disease was associated with high physical activity in Europeans only (RR, 0.62; 95% CI, 0.43–0.91); population-based control studies (RR, 0.56; 95% CI, 0.41–0.76); and case-control studies (RR, 0.56; 95% CI, 0.41–0.75). The data of 6 studies were pooled to analyze the effect of physical activity on the risk of ulcerative colitis, and no significant association was found (RR, 0.82; 95% CI, 0.68–1.00). Conclusions: The pooled results of observational studies support that physical activity has a protective effect against Crohn's disease.