The high-molecular weight multimer form of adiponectin is a useful marker of polycystic ovary syndrome in Bahraini Arab women. (June 2016)

• Record Type: Journal Article
• Authors: Al-Awadi, Amina M.; Sarray, Sameh; Arekat, Mona R.; Saleh, Layal R.; Mahmood, Naeema; Almawi, Wassim Y.
• Is Part Of: Clinical nutrition ESPEN. Volume 13(2016)
• Page Start: e33
• Page End: e38
• Publication Date: 2016-06
• Subjects: Adiponectin -- Androgens -- ELISA -- Insulin resistance -- Polycystic ovary syndrome; Nutritionally induced diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; 616.39005
• DOI: 10.1016/j.clnesp.2016.03.078
• Languages: English
• ISSNs: 2405-4577

Abstract

Summary: Background & aims: We tested if decreased total and high molecular weight (HMW)-adiponectin, and altered HMW/total adiponectin ratio (HMWR) constitute reliable markers of polycystic ovary syndrome (PCOS) among Bahraini Arab women. Methods: Case–control study involving 122 Bahraini Arab women with PCOS and 89 ethnically-matched control women. PCOS was evaluated according to 2003 Rotterdam criteria. Total and HMW-adiponectin were measured by ELISA. Results: Compared to controls, women with PCOS had significantly reduced plasma HMW-adiponectin, and HMWR, more so than total adiponectin. Logistic regression analysis revealed that HMW-adiponectin and HMWR, more than total adiponectin, were negatively associated with PCOS. ROC area-under-the-curve for predicting PCOS were larger for HMW-adiponectin (0.679 ± 0.037), and HMWR (0.653 ± 0.039), than total adiponectin (0.537 ± 0.041). Regression analysis confirmed the association of low HMW-adiponectin and HMWR with PCOS. HMW-adiponectin and HMWR inversely correlated with age, BMI, hirsutism, insulin, HOMA-IR, and positively correlated with serum LDL-cholesterol. Total adiponectin was negatively correlated with waist–hip ratio and serum LH levels. Conclusions: Reduction in adiponectin plasma levels is an independent risk factor for PCOS. Changes in HMW-adiponectin serum levels and HMW/total adiponectin ratio are better markers for the presence of PCOS, when compared with total adiponectin. Highlights: Total and high molecular weight HMW-adiponectin are independent predictors of PCOS. PCOS women had reduced HMW-adiponectin, and HMWR, but not total adiponectin. HMW-adiponectin and HMWR correlated with age, BMI, hirsutism, insulin, HOMA-IR. Reduction in adiponectin secretion is an independent risk factor for PCOS.