Synthesis of α-keto imides through copper-catalyzed oxidation of N-sulfonyl ynamides. Issue 48 (28th November 2017)

• Record Type: Journal Article
• Authors: Liu, Xin; Zhang, Zhi-Xin; Zhou, Bo; Wang, Ze-Shu; Zheng, Ren-Hua; Ye, Long-Wu
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 48(2017)
• Page Start: 10156
• Page End: 10159
• Publication Date: 2017-11-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02728a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A novel copper-catalyzed N -oxide oxidation of N -sulfonyl ynamides has been developed, allowing the facile synthesis of various α-keto imides in generally moderate to good yields. Abstract : A novel copper-catalyzed N -oxide oxidation of N -sulfonyl ynamides is disclosed. This non-noble metal-catalyzed protocol enables facile and efficient access to valuable α-keto imides in generally good to excellent yields. Other notable features of this method include widespread availability of the substrates, compatibility with broad functional groups, a simple procedure, mild conditions, and in particular, no need to exclude moisture or air ("open flask").