Albumin-coordinated assembly of clearable platinum nanodots for photo-induced cancer theranostics. (February 2018)

• Record Type: Journal Article
• Authors: Tang, Yong'an; Yang, Tao; Wang, Qiaoli; Lv, Xiaoyan; Song, Xue; Ke, Hengte; Guo, Zhengqing; Huang, Xiaoqing; Hu, Jun; Li, Zifu; Yang, Peng; Yang, Xiangliang; Chen, Huabing
• Is Part Of: Biomaterials. Volume 154(2018)
• Page Start: 248
• Page End: 260
• Publication Date: 2018-02
• Subjects: Albumin -- Platinum nanodot -- Theranostics -- Multimodal imaging -- Photothermal therapy; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2017.10.030
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Photoactive noble metal nanoparticles are of increasing importance toward personalized cancer therapy in the field of precision nanomedicine. A critical challenge remains in the exploration of clinically potential noble metal nanoparticles for highly efficient cancer theranostics. Here, we introduce albumin-coordinated assembly of clearable Pt nanodots (Pt-NDs) with monodisperse nanostructure as high-performance theranostic agents for imaging-guided photothermal tumor ablation. We precisely manipulate the reduction and growth of tetravalent Pt ions into ultrasmall nanodots through albumin-directed growth kinetics, thereby leading to the synthesis of monodisperse 6.7 nm Pt-NDs with albumin molecules as the corona. Pt-NDs exhibit the surface plasmon resonance at 225 nm with enhanced near-infrared (NIR) absorbance, ideal resistance to photo-bleaching, distinct photoacoustic and X-ray signals, as well as remarkable photothermal effect through non-radiative relaxation under NIR light irradiation. In particular, Pt-NDs possess preferable tumor accumulation, and effective in vivo excretory capability. Thus, these nanodots promote preferable in vivo microscopic photoacoustics and spatially anatomic CT imaging with enhanced contrast, as well as potent hyperthermia-mediated tumor ablation. These findings represent a facile and general approach to fabricate high-performance noble metal nanostructures with clinical potential for cancer theranostics. Graphical abstract: We demonstrate an albumin-coordinated assembly of multifunctional platinum nanodots with clinical potential for photo-induced tumor imaging and simultaneous photothermal tumor ablation.