Bioluminescence probe for γ-glutamyl transpeptidase detection in vivo. Issue 1 (1st January 2018)

• Record Type: Journal Article
• Authors: Lin, Yuxing; Gao, Yuqi; Ma, Zhao; Jiang, Tianyu; Zhou, Xin; Li, Zhenzhen; Qin, Xiaojun; Huang, Yun; Du, Lupei; Li, Minyong
• Is Part Of: Bioorganic & medicinal chemistry. Volume 26:Issue 1(2018)
• Page Start: 134
• Page End: 140
• Publication Date: 2018-01-01
• Subjects: Bioluminescence probe -- γ-Glutamyl transpeptidase -- In vivo imaging; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2017.11.025
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: To detect γ-Glutamyl Transpeptidase (GGT) activity in vitro and in vivo, a bioluminescence probe with high sensitivity and specificity was well designed and synthesized. This probe can be recognized by GGT and release strong bioluminescence with its further reaction with luciferase. The performance of this probe was demonstrated in vitro and in cells. Finally, we applied the probe for detection of GGT activity in xenograft model.