PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development. (1st February 2018)

• Record Type: Journal Article
• Authors: Mao, Ziming; Liu, Chunying; Lin, Xuejing; Sun, Bin; Su, Changqing
• Is Part Of: Cancer letters. Volume 414(2018)
• Page Start: 222
• Page End: 229
• Publication Date: 2018-02-01
• Subjects: Protein phosphatase -- PPP2R5A -- Tumor -- Molecular mechanism -- Signaling pathway; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2017.11.024
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A) is one of the regulatory subunits of the protein phosphatase 2A (PP2A), which is a major member of protein serine/threonine phosphatases in cells. PPP2R5A can regulate the cellular location, substrate specification and protein phosphatase function of PP2A, through which PPP2R5A plays an important role in many cellular activities. It has been reported that PPP2R5A relates with many diseases including some kinds of cancers, but the related mechanisms have a lot remaining to be discovered or demonstrated. This review arms to summarize PPP2R5A and its relationships with the occurrence and progression of tumors, helping us to further understand its significance in the prevention, early diagnosis, targeted therapy and prognosis improvement of tumors. Highlights: PPP2R5A is a major member of protein serine/threonine phosphatases in human cells and plays an important role in many cellular activities. PPP2R5A relates with many diseases including cancers by regulating many crucial signaling pathways involved in P53, Bcl-2, CDK, MAPK, JAK/STAT, c-Myc and β-Catenin. Dysfunctions of PPP2R5A are often involved in cancers as cancer suppressor or cancer promoter. What function that PPP2R5A may exert depends on PPP2R5A's regulatory factors, substrates and the status of PPP2R5A.