Recent topics of phosphine-mediated reactions. Issue 2 (10th January 2018)

• Record Type: Journal Article
• Authors: Karanam, Praneeth; Reddy, Ganapuram Madhusudhan; Koppolu, Srinivasa Rao; Lin, Wenwei
• Is Part Of: Tetrahedron letters. Volume 59:Issue 2(2018)
• Page Start: 59
• Page End: 76
• Publication Date: 2018-01-10
• Subjects: Phosphine-mediated reactions -- Wittig reactions -- Kukhtin-Ramirez adducts -- Huisgen zwitterions -- Annulations; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.11.051
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Recent advances in stoichiometric phosphine-mediated reactions have been summarized. Phosphines have excellent nucleophilicity, oxyphilicity, basicity and leaving group ability. Recent reports are categorized based on type of intermediate/reaction involved. This review provides good insight of recent research and future perspectives. Abstract: Phosphines constitute key organophosphorus reagents that are being widely used in industry as well as in research laboratories since over a century. Specifically, in last two decades, there have been numerous reports on phosphine-mediated and phosphine-catalyzed reactions. In terms of industrial application, phosphine-mediated reactions have received much attention when compared to the catalytic versions for the synthesis of a variety of structurally diverse organic frameworks. In this digest review, we wish to summarize the recent advances (2014–2017) in phosphine-mediated reactions that are primarily based on stoichiometric application of phosphine.