Salvihispin A and its glycoside, two neo-clerodane diterpenoids with neurotrophic activities from Salvia hispanica L. Issue 2 (10th January 2018)

• Record Type: Journal Article
• Authors: Fan, Min; Zhu, Yu; Zhang, Zhi-Jun; Du, Ru-Nan; Zhu, Qin-Feng; Wu, Xing-De; Zhao, Qin-Shi
• Is Part Of: Tetrahedron letters. Volume 59:Issue 2(2018)
• Page Start: 143
• Page End: 146
• Publication Date: 2018-01-10
• Subjects: neo-Clerodane diterpenoids -- Salvia hispanica -- Neurotrophic activities; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.12.010
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Isolation of two new neo -clerodane diterpenoids from Salvia hispanica . The diterpenoid glycoside with unusual 3-keto-glucopyranoside unit was verified. The absolute configurations of1 and2 were confirmed by single crystal X-ray data. These new compounds exhibit neurotrophic activities. Abstract: A neo -clerodane diterpenoid, salvihispin A (1 ), as well as its glycoside, salvihispin A-2- O - β -d -3-keto-glucopyranoside (2 ) were isolated from the aerial parts of Salvia hispanica . Compound2 possessed an unusual 3-keto-glucopyranoside moiety. Their structures and absolute configurations were elucidated by extensive spectroscopic methods and confirmed by single crystal X-ray diffraction. Salvihispin A (1 ) and its glycoside (2 ) enhanced the neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 μ M.