The organophosphate malathion disturbs gut microbiome development and the quorum-Sensing system. (February 2018)

• Record Type: Journal Article
• Authors: Gao, Bei; Chi, Liang; Tu, Pengcheng; Bian, Xiaoming; Thomas, Jesse; Ru, Hongyu; Lu, Kun
• Is Part Of: Toxicology letters. Volume 283(2018)
• Page Start: 52
• Page End: 57
• Publication Date: 2018-02
• Subjects: Quorum sensing -- Gut microbiome toxicity -- Malathion; Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2017.10.023
• Languages: English
• ISSNs: 0378-4274

Abstract

Highlights: This study investigated the effects of an organophosphate malathion on gut microbiome development and quorum-sensing. Malathion perturbed gut microbiome development, quorum sensing and quorum-sensing regulated behaviors. These findings may provide novel mechanistic understanding of the role of quorum-sensing in malathion-induced gut microbiome toxicity. Abstract: The gut microbiome has tremendous potential to impact health and disease. Various environmental toxicants, including insecticides, have been shown to alter gut microbiome community structures. However, the mechanism that compositionally and functionally regulates gut microbiota remains unclear. Quorum sensing is known to modulate intra- and interspecies gene expression and coordinate population responses. It is unknown whether quorum sensing is disrupted when environmental toxicants cause perturbations in the gut microbiome community structure. To reveal the response of the quorum-sensing system to environmental exposure, we use a combination of Illumina-based 16S rRNA gene amplicon and shotgun metagenome sequencing to examine the impacts of a widely used organophosphate insecticide, malathion, on the gut microbiome trajectory, quorum sensing system and behaviors related to quorum sensing, such as motility and pathogenicity. Our results demonstrated that malathion perturbed the gut microbiome development, quorum sensing and quorum sensing related behaviors. These findings may provide a novel mechanistic understanding of the role of quorum-sensing in the gut microbiome toxicity of malathion.