Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy. (5th February 2018)

• Record Type: Journal Article
• Authors: Yang, Jinghai; Gao, Fei; Han, Donglai; Yang, Lili; Kong, Xiangwang; Wei, Maobin; Cao, Jian; Liu, Huilian; Wu, Zhitao; Pan, Guoyu
• Is Part Of: Materials & design. Volume 139(2018)
• Page Start: 172
• Page End: 180
• Publication Date: 2018-02-05
• Subjects: Zinc-based nanoplatform -- pH-responsive -- Drug delivery -- Multifunction; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2017.11.004
• Languages: English
• ISSNs: 0264-1275

Abstract

Abstract: Novel multifunctional ZnO@ (Fe3 O4 /ZnS:Mn 2+ ) nanocomposites as a pH-responsive drug delivery system were designed and successfully synthesized by a self-assembling method. The as-prepared ZnO@(Fe3 O4 /ZnS:Mn 2+ ) possess porous hollow structure with strong orange fluorescence and faster magnetic response, which is beneficial for the functions of drug loading, fluorescence labeling and magnetic targeting simultaneously. Both in vitro and in vivo experiments testify that the ZnO@(Fe3 O4 /ZnS:Mn 2+ ) nanocomposites own a good biocompatibility without obvious side effects on both cells and mice. After 24 days of treatment on the mice, ZnO@(Fe3 O4 /ZnS:Mn 2+ ) nanocomposites greatly inhibited the tumor growth without causing both body weight change and any obvious pathological changes in major organs. The better antitumor efficacy than free DOX can be ascribed to both the accumulation of DOX-ZnO@(Fe3 O4 /ZnS:Mn 2+ ) inside tumor and a sustained DOX release due to the dissociation of ZnO@(Fe3 O4 /ZnS:Mn 2+ ) in acidic environment. Graphical abstract: Highlights: Multifunctional hollow nanocomposites as pH-responsive drug delivery system were designed. In vitro and in vivo experiments testified the good biocompatibility of nanocomposites. Nanocomposites inhibited the tumor growth due to sustained drug release in acidic environment.