Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes. Issue 1 (15th November 2017)

• Record Type: Journal Article
• Authors: Fort, Kyle L.; van de Waterbeemd, Michiel; Boll, Dmitriy; Reinhardt-Szyba, Maria; Belov, Mikhail E.; Sasaki, Eita; Zschoche, Reinhard; Hilvert, Donald; Makarov, Alexander A.; Heck, Albert J. R.
• Is Part Of: Analyst. Volume 143:Issue 1(2018)
• Page Start: 100
• Page End: 105
• Publication Date: 2017-11-15
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/c7an01629h
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : Native mass spectrometry can provide insight into the structure of macromolecular biological systems. Abstract : Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m / z measurable are described.