A tailored nanosheet decorated with a metallized dendrimer for angiography and magnetic resonance imaging-guided combined chemotherapy. Issue 1 (12th December 2017)

• Record Type: Journal Article
• Authors: Zhang, Guilong; Du, Ruohong; Qian, Junchao; Zheng, Xiaojia; Tian, Xiaohe; Cai, Dongqing; He, Jiacai; Wu, Yiqun; Huang, Wei; Wang, Yuanyin; Zhang, Xin; Zhong, Kai; Zou, Duohong; Wu, Zhengyan
• Is Part Of: Nanoscale. Volume 10:Issue 1(2018)
• Page Start: 488
• Page End: 498
• Publication Date: 2017-12-12
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c7nr07957e
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : A highly efficient nanosystem is produced for MRI-guided chemotherapy and angiography. Abstract : Considering the chemical exchange between gadolinium centers and water protons, nanosystems comprising gadolinium conjugated with high specific area nanocarriers might serve as more robust clinical tools for diagnosis and imaging-guided therapy. Herein, a pH-responsive nanosystem containing graphene oxide conjugated with a folic acid- and gadolinium-labeled dendrimer (FA-GCGLD) to boost its T 1 contrast ability was developed, and doxorubicin (DOX) and colchicine (COLC) were efficiently loaded onto this nanosystem (FA-GCGLD-DOX/COLC). This nanosystem showed a prominent T 1 contrast with an ultrahigh relaxivity of up to 11.6 mM −1 s −1 and pH-responsive drug release behavior. HepG2 cells treated with FA-GCGLD-DOX/COLC were efficiently inhibited, and the cell contrast was enhanced. In vivo, the tumor accumulation of FA-GCGLD-DOX/COLC significantly increased, thereby facilitating the systemic delivery of particles and exerting tumor growth inhibition and an enhanced tumor contrast effect. Moreover, compared to free drugs, FA-GCGLD-DOX/COLC effectively decreased the drug resistance of the tumor, thereby improving the cancer chemotherapeutic efficacy. In addition, injecting rats with FA-GCGLD afforded excellent magnetic resonance angiography (MRA) images with high-resolution vascular structures because of the long blood circulation time of FA-GCGLD. Thus, this study provides a powerful tool for diverse applications in the biomedical field, including accurate diagnosis and chemotherapy of tumors and the detection of cardiovascular diseases.