Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor. Issue 48 (7th November 2017)

• Record Type: Journal Article
• Authors: Bag, Subhendu Sekhar; Pradhan, Manoj Kumar; Talukdar, Sangita
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 48(2017)
• Page Start: 10145
• Page End: 10150
• Publication Date: 2017-11-07
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02433a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Specific sensing of dimericH45 G-quadruplex DNA using a fluorescence light-up probe, tetrazolylpyrene nucleoside ( TzPy B Do ), is reported. Abstract : We report herein the specific sensing of dimericH45 G-quadruplex DNA via a fluorescence light-up response using fluorescent tetrazolylpyrene nucleoside ( TzPy B Do ) as a probe. The strong binding of the probe via an intercalative stacking interaction inside the connecting loop of two G-quadruplex units ofH45 and the discrimination to other monomeric and long DNA duplexes are accompanied by a drastic enhancement of the emission intensity without compromising the conformation and stability.