Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition. Issue 99 (29th November 2017) - Belle, Roman
Abstract : Writers, erasers and readers show the selectivity for the acceptance of (methyl)d -lysine. Abstract : Histone lysine methylation is regulated by N ε -methyltransferases, demethylases, and N ε -methyl lysine binding proteins. Thermodynamic, catalytic and computational studies were carried out to investigate the interaction of three epigenetic protein classes with synthetic histone substrates containingl - andd -lysine residues. The results reveal that out of the three classes, N ε -methyl lysine binding proteins are superior in accepting lysines with thed -configuration.